| Name | RS 09 TFA |
| Description | RS 09 TFA is a TLR4 agonist and LPS peptide analogue that promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages. It restores macrophage polarisation and inflammatory responses while disrupting the neuroprotective effects of ciliary proteins. |
| In vitro | In HEK-BLUETM-4 cells, RS 09 TFA (1-10 μg/mL, 24 hours) can stimulate TLR-4 and activate NF-κB[1]. In RAW264.7 cells, RS 09 TFA (5 μg/mL, 15 minutes-24 hours) binds to TLR-4 and induces NF-κB nuclear translocation as well as the secretion of inflammatory cytokines[1]. |
| In vivo | RS 09 TFA serves as an immune adjuvant, combined with the prostate cancer-specific antigen X-15 (conjugated to the carrier protein KLH) for immunization in BALB/c mice. Experimental results demonstrate that this compound can significantly elevate the concentration of X-15-specific antibodies in the mice [1]. |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (4.1 mM), Sonication is recommended.
H2O : ≥ 40 mg/mL, Sonication is recommended.
DMSO : ≥ 80 mg/mL, Sonication is recommended.
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| Inhibitors Related | Sodium propionate | Ethyl palmitate | Kojic acid | Uridine | Hydroxychloroquine | Fumaric acid | Benzyl alcohol | 1,4-Naphthoquinone | Glucosamine | Ethyl linoleate | N,N-Dimethylacetamide | Magnesium sulfate |
| Related Compound Libraries | NF-κB Signaling Compound Library | Bioactive Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Transcription Factor-Targeted Compound Library |
United States
