| Name | (RS)-(Tetrazol-5-yl)glycine |
| Description | (RS)-(Tetrazol-5-yl)glycine is a potent and selective N-methyl-D-aspartate (NMDA) receptor agonist that can induce seizure models and Fos expression in mice. Its EC50 values for GluN1/GluN2D and GluN1/GluN2A are 99 nM and 1.7 μM, respectively. |
| In vitro | (RS)-(Tetrazol-5-yl)glycine does not significantly inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM). It displaces NMDA receptor binding to rat brain membranes using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands [1]. |
| In vivo | (RS)-(Tetrazol-5-yl)glycine is a potent convulsant in neonatal rats (ED50=0.071 mg/kg; i.p.) and induces seizure responses and Fos in NR1+/+ and NR1-/- mice (1.25, 1.5 mg/kg; IP) [1][3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : < 1.43 mg/mL (10 mM, insoluble or slightly soluble)
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| Keywords | seizure | NMDA | LY-285265 | LY285265 | Ionotropic glutamate receptors | Inhibitor | inhibit | iGluR | GluN2D | GluN2A | GluN1/GluN2D | GluN1/GluN2A | GluN1 | Fos | (RS)-(Tetrazol-5-yl)glycine | (RS)(Tetrazol5yl)glycine | (RS) (Tetrazol 5 yl)glycine |
| Inhibitors Related | Urethane | Decanoic Acid | N-Methylsarcosine | L-Glutamic acid | N,N-Dimethylglycine hydrochloride | L-Phenylalanine | glycine | Halothane | Indole-2-carboxylic acid | L-Glutamic acid monosodium salt | Memantine | Memantine hydrochloride |
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