| Name | Rupintrivir |
| Description | Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be useful for the study of viral infections. |
| In vitro | In H1-HeLa and MRC-5 cell protection assays, Rupintrivir (AG7088) inhibited the replication of all HRV serotypes (48 of 48) tested with a mean 50% effective concentration (EC50) of 0.023 microM (range, 0.003 to 0.081 microM) and a mean EC90 of 0.082 microM (range, 0.018 to 0.261 microM) as well as that of related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11[1]. |
| In vivo | PCLS from HDM-sensitized mice showed an attenuated antiviral response, but exaggerated IL-4, IL-6, and IL-10 secretion upon infection. Rupintrivir(AG7088) inhibited exaggerated pro-inflammatory cytokine IL-6 and TH-2 cytokine IL-4 in HDM-sensitized mice[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 2 mg/mL (3.34 mM), Sonication is recommended. DMSO : 252.5 mg/mL (421.78 mM), Sonication is recommended.
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| Keywords | VirusProtease | Virus Protease | Rupintrivir | Enterovirus 71 (EV71) | Antiviral | AG 7088 |
| Inhibitors Related | Rifampicin | Esculin | Phenytoin sodium | Levofloxacin hydrochloride | Hexane-2,5-dione | Ribavirin | L-Lysine | Sodium formate | Ofloxacin | Vidarabine | Thymidine | Danthron |
| Related Compound Libraries | Bioactive Compound Library | ReFRAME Related Library | Protease Inhibitor Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Infection Compound Library | Human Metabolite Library |