| Name | RWJ-67657 |
| Description | RWJ-67657 (JNJ 3026582) is an orally active, selective p38α and p38β MAPK inhibitor (IC50s: 1 and 11 μM, respectively), with no activity at p38γ and p38δ, and demonstrates cardioprotective effects. |
| In vitro | RWJ-67657 suppresses the release of TNF-α by lipopolysaccharide (LPS)-treated human peripheral blood mononuclear cells (IC50: 3 nM) and the release of TNF-α from peripheral blood mononuclear cells treated with the superantigen staphylococcal enterotoxin B (IC50: 13 nM). RWJ67657 (10 μM; 24 hours) reduces colony formation in MCF-7 cells [2][3]. |
| In vivo | RWJ-67657 inhibits TNF-alpha production in lipopolysaccharide-injected mice (87% inhibition at 50 mg/kg) and in rats (91% inhibition at 25 mg/kg) after oral administration. RWJ-67657 (50 mg/kg; p.o.; once daily for 7 consecutive days) demonstrates effective anti-inflammatory activity. EPC transplantation combined with RWJ-67657 administration synergistically promotes angiogenesis and neurogenesis following diabetic stroke by enhancing endothelial progenitor cell function and reducing inflammation [2][4]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (9.4 mM), Sonication is recommended.
DMSO : 125 mg/mL (293.77 mM), Sonication and heating to 60℃ are recommended.
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| Keywords | RWJ-67657 | RWJ67657 | RWJ 67657 | protective. Anti-inflammatory | p38β | p38α | p38MAPK | p38 MAPK | MCF-7 | JNJ-3026582 | JNJ3026582 | Inhibitor | inhibit | inflammation | cardio | anti-tumor |
| Inhibitors Related | Undecane | Esculin | Bisphenol A | Fumaric acid | Bakuchiol | Skatole | SB 202190 | (-)-Bornyl acetate | Afatinib | FERULIC ACID METHYL ESTER | (Rac)-Hesperetin | Benzyl salicylate |
| Related Compound Libraries | Osteogenesis Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | NO PAINS Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
United States
