| Name | (S)-10-Hydroxycamptothecin |
| Description | (S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor used as a clinical therapeutic agent against hepatoma. |
| Cell Research | Cells are exposed to various concentrations of 10-Hydroxycamptothecin for 72 hours. Cell growth is monitored by the standard MTT assay.(Only for Reference) |
| In vitro | In the CAM model, 10-Hydroxycamptothecin (25 nM) inhibits angiogenesis in a concentration-dependent manner. In mice carrying Colo 205 xenografts, oral administration of 10-Hydroxycamptothecin (2.5-7.5 mg/kg) every two days significantly suppresses tumor cell growth. |
| In vivo | (S)-10-Hydroxycamptothecin inhibits cell growth in BT-20 cells (IC50=34.3 nM) and MDA-231 cells (IC50=7.27 nM), demonstrating its efficacy. It also induces the formation of cleavable complexes mediated by human topoisomerase I in pBR322 plasmid DNA (EC50=0.35 μM). Additionally, in human microvascular endothelial cells (HMEC), (S)-10-Hydroxycamptothecin dose-dependently inhibits cell growth (IC50=0.31 μM), significantly hampers HMEC migration (IC50=0.63 μM), and impedes angiogenesis (IC50=0.96 μM). |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 26 mg/mL (71.36 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
|
| Keywords | Topoisomerase | Topo I | PCNA | p53 | G2/M | c-Myc | Cell-cycle | caspase-1/3r | Bcl-2 | Bax | arrest | Apoptosis | antitumor | (S)10Hydroxycamptothecin | (S) 10 Hydroxycamptothecin |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Alkaloid Natural Product Library | Natural Product Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Natural Product Library for HTS | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
