| Name | (S)-Coriolic acid |
| Description | (S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent generated by the reaction of linoleic acid with plant and mammalian lipoxygenases. It is involved in cell proliferation and differentiation in various biological systems and inhibits the adhesion of tumor cells to the vascular endothelium, while down-regulating IRGpIIb/IIIa receptor expression at around 1 μM. Additionally, (S)-Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX) and often acts as an endogenous ligand to activate PPARγ. It induces mitochondrial dysfunction and airway epithelial damage. |
| In vitro | (S)-Coriolic acid (30 nM; 6 h; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB.[3] |
| In vivo | (S)-Coriolic acid (0-0.6 mg; intranasal; once daily for 3 consecutive days; mouse) induces significant airway dysfunction, neutrophilia, mitochondrial dysfunction, and epithelial injury.[2] |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : >50 mg/mL (per Rao Maddipati), Sonication is recommended.
DMSO : 55 mg/mL (185.54 mM), Sonication is recommended.
PBS (pH 7.2) : 1 mg/mL (3.37 mM), Sonication is recommended.
DMF : >50 mg/mL (per Rao Maddipati), Sonication is recommended.
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| Keywords | PPARγ | MitochondrialMetabolism | Mitochondrial Metabolism | Coriolic acid | 15 LOX | 13HODE |
| Inhibitors Related | Rosiglitazone | Caffeic Acid | Phenidone | Daidzein | 4-Aminosalicylic acid | Magnesium acetate tetrahydrate | Maltitol | (-)-Epigallocatechin Gallate | Sodium Molybdate | 2,3-Butanediol | 4-Pentenoic acid | Cloxiquine |
| Related Compound Libraries | Anti-COVID-19 Traditional Chinese Medicine Compound Library | Anti-Obesity Compound Library | Anti-Aging Compound Library | Human Endogenous Metabolite Compound Library Plus | Tibetan medicine Compound Library |
United States
