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S-(+)-Ketoprofen NEW

$2.00 100kg

$4.00 10kg

$5.00 1kg

Min. Order1kg
Purity99%
Cas No22161-81-5
Supply Ability100kg
Update time2025-10-13

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

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Chemical Properties

Product Name	S-(+)-Ketoprofen
CAS No	22161-81-5
EC-No
Min. Order	1kg
Purity	99%
Supply Ability	100kg
Release date	2025/10/13

PRODUCT INFORMATION

Name	dexketoprofen
Synonym	More Synonyms

Description	S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively.
Related Catalog	Research Areas >> Inflammation/Immunology
Target	COX-1:13 μM (IC50) COX-2:370 μM (IC50)
In Vitro	S-(+)-Ketoprofen (Compound 1) is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively[1].
References	[1]. Palomer A, et al. Modeling cyclooxygenase inhibition. Implication of active site hydration on the selectivity ofketoprofen analogues. J Med Chem. 2000 Jun 1;43(11):2280-4.

Density	1.2±0.1 g/cm3
Boiling Point	431.3±28.0 °C at 760 mmHg
Melting Point	75-78ºC(lit.)
Molecular Formula	C16H14O3
Molecular Weight	254.281
Flash Point	228.8±20.5 °C
Exact Mass	254.094299
PSA	54.37000
LogP	2.81
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.592
Storage condition	-20°C Freezer

Material Safety Data Sheet

Section1. Identiﬁcation of the substance
Product Name: (S)-(+)-Ketoprofen
Synonyms:

Section2. Hazards identiﬁcation
Harmful by inhalation, in contact with skin, and if swallowed.

H301:Toxic if swallowed
H315:Causes skin irritation
H319:Causes serious eye irritation
H335:May cause respiratory irritation
Very toxic to aquatic life
H400:
P261:Avoid breathing dust/fume/gas/mist/vapours/spray
P273:Avoid release to the environment
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing

Section3. Composition/information on ingredients.
Ingredient name:(S)-(+)-Ketoprofen
CAS number:22161-81-5

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not speciﬁed
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula: C16H14O3
Molecular weight: 254.3

Section10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
UN Number:UN2811Class: 6.1Packing group: III
Proper shipping name: TOXIC SOLIDS, ORGANIC, N.O.S. ((S)-(+)-Ketoprofen)

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CY1572790

CHEMICAL NAME :
Benzeneacetic acid, 3-benzoyl-alpha-methyl-, (S)-

CAS REGISTRY NUMBER :
22161-81-5

LAST UPDATED :
199606

DATA ITEMS CITED :
1

MOLECULAR FORMULA :
C16-H14-O3

MOLECULAR WEIGHT :
254.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
225 mg/kg/90D-I

TOXIC EFFECTS :
Gastrointestinal - other changes

REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 30,101,1996

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335-H400
Precautionary Statements	P261-P273-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R25;R36/37/38
Safety Phrases	26-60-61
RIDADR	UN 2811 6
WGK Germany	3
RTECS	CY1572790
Hazard Class	6.1
HS Code	2942000000

Ethyl 2-(3-benz...

60658-04-0

~23%

S-(+)-Ketoprofe...

22161-81-5

Literature: Hernaiz, Maria J.; Sanchez-Montero, Jose M.; Sinisterra, Jose V. Tetrahedron, 1994 , vol. 50, # 36 p. 10749 - 10760

Ethyl 2-(3-benz...

60658-04-0

S-(+)-Ketoprofe...

22161-81-5

(2R)-2-(3-Benzo...

56105-81-8

Literature: Journal of Molecular Catalysis B: Enzymatic, , vol. 85-86, p. 23 - 30

ketoprofen

22071-15-4

~94%

S-(+)-Ketoprofe...

22161-81-5

Literature: Camps; Farres; Mauleon; Palomer; Carganico Synthetic Communications, 1993 , vol. 23, # 12 p. 1739 - 1758

Precursor 8	Previous 1/2 Next
CAS#:60658-04-0 Ethyl 2-(3-benz... CAS#:22071-15-4 ketoprofen CAS#:59512-44-6 3-benzoyl-α-met... CAS#:57872-48-7 methyl α-(m-ben...
DownStream 1
CAS#:66067-43-4 3-Ehylbenzophenone

HS Code	2942000000

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