| Name | Safranal |
| Description | Safranal is the special volatile aroma compound of saffron.Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson's disease research. |
| In vitro | At first, the potential toxic effect of safranal on OLN-93 viability was evaluated. Also, the cells were pretreated with safranal (0.1, 1, 10, 50, 100 and 200 μM) for 2 h and then subjected to glutamic acid (16 mM) or quinolinic acid (8 mM) toxicity for 24 h, in which the same treatments were applied. Results: Safranal at concentration ranges of 1-800 μM had no toxic effect on cell viability (p>0.05). Treatment with safranal significantly increased cell viability following glutamic acid or quinolinic acid insults at concentrations higher than 1 μM (p<0.01). The cytoprotective potential of safranal was also accompanied by decreased ROS accumulation (p<0.001) and malondialdehyde level (p<0.001) following glutamic acid or quinolinic acid insults. The data suggests that safranal exhibits oligoprotection potential by means of inhibiting oxidative stress parameters. |
| In vivo | Safranal (200-500 mg/kg; PO; for 7 days) slightly restores colon length and reduces weight loss percentage, significantly lowering the DAI score[2]. |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (26.63 mM), Sonication is recommended.
DMSO : 250 mg/mL (1664.23 mM), Sonication is recommended.
Ethanol : 100 mg/mL (665.69 mM), Sonication is recommended.
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| Keywords | Safranal | Saffron | Parkinson's | orally | neuroprotective | Inhibitor | inhibit | disease | Antioxidant | anti-inflammatory |
| Inhibitors Related | Aceglutamide | Maltol | Dimethyl fumarate | AFMK | Curcumin | DL-alpha-Tocopherylacetate | Neohesperidin | Sulbutiamine | L-Methionine | L-Cystine | γ-Terpinene | Tyrosol |
| Related Compound Libraries | Terpene Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Flavor Natural Product library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
United States
