| Name | Saikogenin D |
| Description | Saikogenin D possesses dual mechanisms of action including inhibition of A23187-induced PGE2 production without direct cyclooxygenase suppression, and stimulation of intracellular calcium elevation through Ca2+ release from internal stores, while further displaying immunomodulatory properties demonstrated by its ability to attenuate IL-6 production in LPS-stimulated alveolar macrophages from B6 mice more strongly than in BALB mice, highlighting selective regulation of inflammatory responses. |
| In vitro | In C6 rat glioma cells, Saikogenin D (1-20 μM) inhibited calcium ionophore A23187-induced PGE2 production in a concentration-dependent manner, with an IC50 of 3 μM[1].
In C6 rat glioma cells, Saikogenin D (10-100 μM) increased intracellular calcium concentration ([Ca²⁺]i) in a concentration-dependent manner regardless of the presence of extracellular calcium ions, with an EC50 of 35 μM[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : ≥ 80 mg/mL, Sonication is recommeded.
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| Keywords | Saikogenin D | ProstaglandinReceptor | Prostaglandin Receptor | PGE | ILReceptor | IL Receptor | CalciumChannel | Calcium Channel |
| Inhibitors Related | Quadrol | 2,4,6-Tri-tert-butylphenol | Chlorocresol | L-Ascorbic acid | 1,8-Cineole | Tetraethylammonium bromide | Chenodeoxycholic acid | L-Ascorbic acid sodium salt | 2-Nitrobenzoic acid | Diallyl disulfide | Magnesium Chloride Hexahydrate | Magnesium sulfate |
| Related Compound Libraries | Terpene Natural Product Library | Bioactive Compound Library | Calcium Channel Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |