
Property Description
IUPAC Name:Sarolaner
CAS:1398609-39-6
Molecular Formula:C₃₂H₃₃Cl₂F₄N₃O₅S
Molecular Weight:718.59 g/mol
CAS Number:13986
Appearance:White to off-white powder
Solubility:Insoluble in water; soluble in DMSO, ethanol
Melting Point:150–155°C (decomposes)
Chemical Class:Isoxazoline derivative
Mechanism of Action:GABA/glutamate-gated chloride channel inhibitor (arthropod-specific)
Primary Use:Veterinary ectoparasiticide (fleas & ticks)
Target Animals:Dogs, cats
Commercial Products:Simparica® (Zoetis), Revolution® Plus (Selamectin + Sarolaner)
Regulatory Approvals:FDA (USA), EMA (EU), others (market-dependent)
Key Benefits:Long-lasting protection (up to 1 month), broad-spectrum efficacy, low mammalian toxicity

| Parameter | Specification | Test Method |
|---|
| Appearance | White to off-white powder | Visual inspection |
| Identification | Complies (HPLC/IR vs. reference standard) | HPLC, IR spectroscopy |
| Purity (HPLC) | ≥ 98.0% | Reverse-phase HPLC |
| Water Content (KF) | ≤ 0.5% w/w | Karl Fischer titration |
| Residue on Ignition | ≤ 0.1% | USP <281> |
| Heavy Metals | ≤ 10 ppm (as Pb) | ICP-MS / USP <231> |
| Related Substances | Total impurities ≤ 2.0% Any single impurity ≤ 0.5% | HPLC (area normalization) |
| Particle Size | 90% ≤ 100 µm (customizable) | Laser diffraction (if applicable) |
| Solubility | Insoluble in water; soluble in DMSO/ethanol | Solubility test |
| Microbial Limits | Total aerobic count ≤ 1000 CFU/g Yeast/mold ≤ 100 CFU/g No pathogens detected | USP <61>, <62> |
| Storage Conditions | 2–8°C (dry, protected from light) | Label requirement |
| Shelf Life | 24 months (unopened, under recommended storage) | Stability studies |
