| Name | SC-514 |
| Description | SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression. |
| In vitro | In nude mice implanted with A375 or G361 tumors, daily treatment was administered with SC-514 (25 mg/kg). |
| In vivo | In rheumatoid arthritis synovial fibroblasts (RASFs), SC-514 (100 μM) inhibits the phosphorylation and degradation of IκBα, while also preventing the translocation of p65 into the nucleus. In the presence of IL-1β-induced inflammation, SC-514 effectively suppresses the expression of NF-κB-dependent genes: IL-6 (IC50=20 μM), IL-8 (IC50=20 μM), and COX-2 (IC50=8 μM). |
| Storage | 02 | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 40 mg/mL (178.33 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.92 mM), Sonication is recommended. Ethanol : 2.2 mg/mL (9.81 mM), Sonication is recommended.
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| Keywords | SerineProtease | Serine Protease | SC-514 | SC514 | SC 514 | PRAK | p38α | p38MAPK | p38 MAPK | IκB kinase | IκB | Inhibitor | inhibit | IKK2 | IKK | IkB/IKK | IkB | I kappa B kinase | GK-01140 | GK01140 | CDK2/CyclinA | AuroraKinase | Aurora Kinase | Aurora B |
| Inhibitors Related | Undecane | Ribociclib | Esculin | Bisphenol A | 2-Chloropyrazine | Kojic acid | AEBSF hydrochloride | Fumaric acid | Imidazole | Subtilisin | Proteinase K | Ac-Ala-OH |
| Related Compound Libraries | Highly Selective Inhibitor Library | Bioactive Compound Library | Pain-Related Compound Library | Cancer Cell Differentiation Compound Library | Antidepressant Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Liver Cancer Compound Library |