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ChemicalBook Product Catalog SC99

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SC99 NEW

$34.00 1mg

$77.00 5mg

$118.00 10mg

Min. Order
Purity99.68%
Cas No882290-02-0
Supply Ability10g
Update time2026-04-12

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	SC99
CAS No	882290-02-0
EC-No
Min. Order
Purity	99.68%
Supply Ability	10g
Release date	2026/04/12

Product Introduction

Bioactivity

Name	SC99
Description	SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities
In vitro	SC99 inhibited the phosphorylation of JAK2 and STAT3 in human platelets but had no effects on the phosphorylation of AKT, p65 or Src, all of which are involved in platelet activation.?SC99 inhibited human platelet aggregation induced by collagen and thrombin in a dose-dependent manner.?SC99 inhibited thrombin-induced P-selectin expression and fibrinogen binding to single platelets.?Moreover, SC99 inhibited platelet spreading on fibrinogen and clot retraction mediated by outside-in signaling.?SC99 inhibited platelet aggregation in mice but it did not significantly prolong the bleeding time.?SC99 inhibited platelet activation and aggregation as a STAT3 inhibitor.?This agent can be developed as a promising treatment for thrombotic disorders.
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 82 mg/mL (243.94 mM), Sonication is recommended.
Keywords	STAT3 \| STAT \| SC-99 \| SC99 \| SC 99 \| pocket \| platelet \| phosphorylation \| orally \| OPM2 \| myeloma \| multiple \| mTOR \| Janus kinase \| JAK2 \| JAK \| Inhibitor \| inhibit \| ERK \| c-Src \| ATP-binding \| Apoptosis \| anti-thrombotic \| anti-myeloma \| AKT \| aggregation \| activation
Inhibitors Related	Stavudine \| Aceglutamide \| Urea \| Tamoxifen \| Cysteamine hydrochloride \| Metronidazole \| Citric Acid Triammonium \| Formamide \| Dimethyl phthalate \| Alginic acid \| Sodium Molybdate \| Sildenafil citrate
Related Compound Libraries	Anti-Colorectal Cancer Compound Library \| Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| Kinase Inhibitor Library \| Tyrosine Kinase Inhibitor Library \| JAK-STAT Compound Library \| Inhibitor Library \| Orally Active Compound Library \| Immunology/Inflammation Compound Library \| Bioactive Compounds Library Max \| Fluorochemical Library \| Anti-Liver Cancer Compound Library

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