| Name | Se-Aspirin |
| Description | Se-Aspirin (Se-NSAID-8) has anticancer activity and gastroprotective effects, inhibits activation of proinflammatory and pro-survival NF-ĸB pathways, and inhibits the expression of anti-apoptotic targets downstream of NF-ĸB (e.g., Bcl-xL, Mcl-1, and survivin).Se-Aspirin induces Cell cycle arrest and activation of apoptosis accelerates ulcer healing and can be used to study pancreatic and colorectal cancer. |
| In vitro | Aspirin inhibits COX-1 and COX-2 in human articular chondrocytes with IC50 values of 3.57 μM and 29.3 μM, respectively[1]; Aspirin acetylates serine 530 of COX-1, thereby blocking the synthesis of thromboxane A in platelets and reducing platelet aggregation; Aspirin inhibits COX-2 protein expression by interfering with the binding of CCAAT/enhancer protein beta (C/EBPbeta) to its homologous sites on the COX-2 promoter/enhancer[2]; Aspirin inhibits NF-κB-dependent transcription from the lgκ enhancer and long terminal repeat (LTR) in human immunodeficiency virus (HIV)-transfected T cells[3]; Aspirin inhibits mitochondrial cytochrome c release, activation of p38 MAP kinase, and activation of the ceramide pathway[4]. |
| In vivo | Aspirin (5-150 mg/kg, PO, once) displays significant antipyretic activity in adult yeast-fever male rats. [5] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SeAspirin | Se Aspirin | Mcl-1 | Bcl-xL | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Ethyl linoleate | Formamide | Dimethyl phthalate | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Apoptosis Compound Library | NF-κB Signaling Compound Library | Bioactive Compound Library | Multi-Target Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library | Transcription Factor-Targeted Compound Library |
United States
