| Name | Seladelpar sodium salt |
| Description | Seladelpar sodium salt (MBX-8025) is an orally active and specific PPARδ agonist with an EC50 of 2 nM, demonstrating over 750-fold and 2500-fold selectivity compared to the PPARα and PPARγ receptors, respectively. |
| In vitro | MBX-8025 is an orally active, potent (EC50 = 2 nM) PPARδ agonist, exhibiting 750-fold and 2500-fold higher specificity compared to PPARα and PPARγ receptors, respectively, and is being developed as a lipid-altering agent [2] [3]. |
| In vivo | In a study involving Wt mice on an atherogenic diet, Seladelpar sodium salt administration led to a significant reduction of approximately 18% in body weight (P<0.05), whereas its impact on foz/foz mice under the same diet was minimal. Additionally, this compound significantly lowered serum alanine aminotransferase (ALT) levels in foz/foz mice (P<0.05) and exhibited a similar, though not significant, effect in Wt mice. Seladelpar sodium salt was effective in normalizing serum cholesterol levels and reducing triglycerides across both mouse genotypes (P<0.05). It also eliminated hepatocyte ballooning (P<0.05) and halved the nonalcoholic fatty liver disease (NAFLD) activity score by approximately 50%. Moreover, the compound notably diminished sirius red-positive areas in foz/foz mice (P<0.05) [4]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (107.19 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 2.5 mg/mL (5.36 mM), Sonication is recommended.
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| Keywords | Seladelpar sodium salt | Seladelpar sodium | RWJ-800025 sodium | PPAR-δ | MBX-8025 sodium |
| Inhibitors Related | PHYTOL | Rosiglitazone | Retinoic acid | Daidzein | Fenofibrate | Magnesium acetate tetrahydrate | Maltitol | Naringenin | 2,3-Butanediol | NPC 15199 | Icariin | Cloxiquine |
United States
