| Name | Sepantronium bromide |
| Description | Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity. |
| Cell Research | Cells are seeded in 96-well plates at a density of 5-40 × 103. YM155 is dissolved in DMSO and added to cells for 48 hours. Then the cell count is determined by sulforhodamine B assay. (Only for Reference) |
| Kinase Assay | Promoter-luciferase reporter assay: A 2,767-bp sequence of human survivin gene promoter is isolated from human genomic DNA by PCR using Pyrobest polymerase and the following primers: 5 |
| In vitro | Subcutaneous injection of 3 and 10 mg/kg YM155 into prostate transplantation tumors showed that YM155 completely inhibited the tumor growth of PC-3 with no decrease in weight and no decrease in blood cell count. Moreover, 5 mg/kg YM155 showed 80% tumor inhibition in PC-3 ectopic graft tumors.The combination of YM155 and γ-radiation showed high antitumor activity against H460 or Calu6 xenografts in nude mice. |
| In vivo | Subcutaneous injection of 3 and 10 mg/kg YM155 into prostate transplantation tumors showed that YM155 completely inhibited the tumor growth of PC-3 with no decrease in weight and no decrease in blood cell count. Moreover, 5 mg/kg YM155 showed 80% tumor inhibition in PC-3 ectopic graft tumors.The combination of YM155 and γ-radiation showed high antitumor activity against H460 or Calu6 xenografts in nude mice. |
| Storage | Store at low temperature | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.26 mM), Sonication is recommended.
H2O : 82 mg/mL (184.99 mM), Sonication is recommended.
Ethanol : 6 mg/mL (13.54 mM), Sonication is recommended.
DMSO : 48 mg/mL (108.29 mM), Sonication is recommended.
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| Keywords | YM-155 | YM 155 | Survivin | Sepantronium bromide | Sepantronium | Inhibitor | inhibit | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | Guanidine hydrochloride | Hydroxychloroquine | Enzalutamide | Paeonol | Naringin | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Bioactive Compound Library | ReFRAME Related Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Aging Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-COVID-19 Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
