| Name | Serotonin |
| Description | Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin regulates the nervous system, digestive system and cardiovascular system. |
| In vitro | METHODS: Mouse B16 melanoma cells were treated with Serotonin for 2 days to detect the anti-melanin production activity.
RESULTS: Serotonin is slightly active or inactive in the inhibitory medium dimming, with IC50> 30 μM. [1] |
| In vivo | METHODS: To study the pain hypersensitivity of Serotonin, Serotonin (10 uM; 20 μl was intradermal injected into mice, and the mice were tested at 15, 30, 45, 60, 90, 120, 180 and 240 minutes.
RESULTS: Compared with the control group receiving saline treatment, Serotonin produced a strong hypersensitivity reaction (p<0.001). [2]
METHODS: To study the role of IL-13-mediated 5-HT signaling in the pathogenesis of colitis, Serotonin (100 mg/kg) was subcutaneously injected into male IL-13-deficient mice 3 days before induction of DSS colitis, twice a day for 8 consecutive days.
RESULTS: After inducing DSS colitis, the content of 5-HT in the colon of IL-13-/- mice that received Serotonin increased significantly. [3] |
| Storage | store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (18.73 mM), Sonication is recommended.
DMSO : 255 mg/mL (1447.05 mM), Sonication is recommended.
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| Keywords | Serotonin Receptor | Serotonin | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | COMT | 5-hydroxytryptamine Receptor | 5HTReceptor | 5-HT Receptor | 5HT Receptor |
| Inhibitors Related | Sucrose | Aceglutamide | L-Pyroglutamic acid | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Formamide | Glycerol | Thymidine | Corn starch | Hyaluronic acid sodium (MW 20 kDa) | Gluconate Calcium |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Natural Product Library | Inhibitor Library | Tobacco Monomer Library | Human Endogenous Metabolite Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | GPCR Compound Library | Food as Medicine Compound Library |
United States
