| Name | Sesamin |
| Description | Sesamin is a selective delta 5 desaturase inhibitor in the biosynthesis of polyunsaturated fatty acids and is a lignan abundantly present in sesame oil. It has potent neuroprotective effects against cerebral ischemia. |
| In vitro | In mice, the LD50 of orally administered sesamin is 3800 mg/kg; in rats, the LD50 is 6150 mg/kg. |
| In vivo | Sesamin significantly enhances the activity of liver enzymes involved in fatty acid oxidation, such as Acyl-CoA dehydrogenase, Acyl-CoA oxidase, 3-Hydroxyacyl-CoA dehydrogenase, Enoyl-CoA hydratase, and 3-Ketoacyl-CoA thiolase, as well as the activities of 2,4-Dienoyl-CoA reductase and Δ3,Δ2-Enoyl-CoA isomerase. |
| Storage | Store at low temperature | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 103 mg/mL (290.67 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (11.29 mM), Sonication is recommended.
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| Keywords | Sesamin | polyunsaturated | desaturase | delta | cerbral | biosynthesis |
| Inhibitors Related | Elemicin | T-3364366 | SW209049 | PluriSIn 1 | MK-8245 | (-)-Asarinin | SLC13A5-IN-1 | MF-438 | SCD1 inhibitor-3 | XEN723 | SCD1 inhibitor-4 | GSK1940029 |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Natural Product Library | Neuroprotective Compound Library | Inhibitor Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |