1. Materials information
Use of Silver sulfadiazine
Silver sulfadiazine (AgSD), a sulfonamide antibiotic, effects a dual inhibitory action on bacterial growth by its sulfa moiety (SD-SDZ) that prevents bacterial folate absorption and subsequent DNA synthesis. The silver that is released from Silver sulfadiazine binds and disrupts the DNA structure, precluding bacterial DNA replication[1].
Silver sulfadiazine Biological Activity
| Description | Silver sulfadiazine (AgSD), a sulfonamide antibiotic, effects a dual inhibitory action on bacterial growth by its sulfa moiety (SD-SDZ) that prevents bacterial folate absorption and subsequent DNA synthesis. The silver that is released from Silver sulfadiazine binds and disrupts the DNA structure, precluding bacterial DNA replication[1]. |
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| Related Catalog | Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial |
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| In Vitro | Silver sulfadiazine (AgSD) is a topical antibiotic used to the research of bacterial infection in burns[2]. |
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| References | [1]. Strydom SJ, et al. Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity. Nanomedicine. 2013;9(1):85-93. [2]. Munhoz DR, et al. Alginate films functionalized with silver sulfadiazine-loaded [Mg-Al] layered double hydroxide as antimicrobial wound dressing. Int J Biol Macromol. 2019;141:504-510. |
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Chemical & Physical Properties
| Density | 1.496g/cm3 |
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| Boiling Point | 512.6ºC at 760 mmHg |
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| Melting Point | 285 °C (dec.)(lit.) |
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| Molecular Formula | C10H9AgN4O2S |
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| Molecular Weight | 357.137 |
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| Flash Point | 263.8ºC |
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| Exact Mass | 355.949707 |
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| PSA | 94.32000 |
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| LogP | 3.11490 |
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| Vapour Pressure | 1.28E-10mmHg at 25°C |
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| Storage condition | Hygroscopic, Refrigerator, Under Inert Atmosphere |
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| Stability | Stable. Incompatible with strong oxidizing agents. |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
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