| Name | Silybin B |
| Description | Silybin B (Silibinin B) is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with free radical scavenging activity of 1, 1-diphenyl-2-pyridinyl hydrazine (DPPH), and a protective effect against cisplatin-induced neurotoxicity by alleviating DNA damage and apoptosis. Silybin B can inhibit the growth of human chronic myeloid leukemia K562 cells and induce apoptosis. |
| In vitro | The present study assessed the effects of the diastereoisomers on cell apoptosis, and compared these with their mixture, silybin, in human chronic myeloid leukemia K562 cells. Both isomers showed stronger effects on cell growth inhibition and apoptosis induction than silybin. Compared with Silybin B, silybin A showed higher effects on the production of intracellular reactive oxygen species and Ca2+.[1] |
| In vivo | Silybin B markedly improved the behavioral abnormalities in cisplatin-treated mice and reduced LPO levels while increasing SOD, GSH, and T-AOC in mice brain tissue. Nissl staining and Tunel assay showed that silybin B alleviated cisplatin-induced hippocampal damage.[2] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 225 mg/mL (466.38 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (10.36 mM), Sonication is recommended.
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| Keywords | βAmyloid | β Amyloid | Silybin B | ROS | DPPH | Calcium Channel | BetaAmyloid | Beta Amyloid | Bcr-Abl (K562 cell line) | BcrAbl | bAmyloid | b Amyloid | Apoptosis | amyloid-β |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Rare Natural Product Library | Kinase Inhibitor Library | Selected Plant-Sourced Compound Library | Tyrosine Kinase Inhibitor Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
