| Name | Silymarin |
| Description | Silymarin is a natural polyphenolic flavonolignan mixture extracted from the seeds of Silybum marianum. It can inhibit tumor cell proliferation and angiogenesis, and improve insulin resistance, thus being widely used in liver disease-related research and adjuvant applications. Studies have shown that silymarin exhibits inhibitory activity against the SARS-CoV-2 main protease, and it has potential research value in the mechanism-related studies of COVID-19. |
| In vitro | Mechanism of Silymarin involves different biochemical reactions, such as stimulation of the rate of ribosomal RNA synthesis by stimulating the transcription of polymerase I and ribosomal RNA genes, blockage of alpha-glycoside loops toxin intake, and protection of cell membranes from free radical-induced damage. Silymarin also displays a substantial protective effect against UVB-induced canceration at different stages, possibly through its strong antioxidant properties. |
| In vivo | The intravenous injection LD50 of Silymarin is 391.4 mg/kg, 70.1 mg/kg, 142.3 mg/kg for mice, rats, rabbits, respectively. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 71.00 mg/mL (147.17 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.50 mg/mL (5.18 mM), Sonication is recommended.
50% PEG300+50% saline : 20.00 mg/mL (41.46 mM), Suspension.
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 1.00 mg/mL (2.07 mM), Sonication is recommended.
|
| Keywords | thistle | Silymarin | Silybin B | SARS-CoV | SARSCoV | SARS coronavirus | resistance | proliferation | Milk | insulin | Inhibitor | inhibit | hepatocellular | HCC | chemopreventive | carcinoma | angiogenesis |
| Inhibitors Related | Nirmatrelvir | EIDD-1931 | Remdesivir | Molnupiravir | Umifenovir hydrochloride | Hydroxychloroquine | Ritonavir | Chloroquine phosphate | Dexamethasone acetate | α-Cyclodextrin | Dexamethasone | Clofoctol |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Polyphenolic Natural Product Library | Failed Clinical Trials Compound Library | Miao medicine Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | NO PAINS Compound Library | Anti-virus Traditional Chinese Medicine Monomer Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Anti-COVID-19 Compound Library |
United States
