| Name | Sinensetin |
| Description | Sinensetin (Pedalitin permethyl ether) is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis. |
| In vitro | Sinensetin promots adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels. Sinensetin shows anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α). |
| In vivo | Sinensetin has the most potent antiangiogenesis activity and the lowest toxicity, inhibits angiogenesis by inducing cell cycle arrest in the G0/G1 phase in HUVEC culture and downregulating the mRNA expressions of angiogenesis genes flt1, kdrl, and hras in zebrafish. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 25.79 mg/mL (69.26 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.69 mM), Sonication is recommended.
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| Keywords | Tumor Necrosis Factor Receptor | TNFR | TNF Receptor | Sinensetin | Prostaglandin E synthase | PGESynthase | PGE synthase | Inhibitor | inhibit | hPGDS |
| Inhibitors Related | Kaolin | Undecane | Fluorene | Acetylcysteine | Ethyl palmitate | Gum arabic | 1,8-Cineole | Dodecane | 1,4-Naphthoquinone | Tributyrin | Glucosamine | Apremilast |
| Related Compound Libraries | Flavonoid Natural Product Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Tobacco Monomer Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Flavor Natural Product library | Bitter Compound library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library |