| Name | SIRT7 inhibitor 97491 |
| Description | SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway. |
| In vitro | SIRT7 inhibitor 97491 (1-10 μM) effectively reduces the proliferation of human uterine sarcoma MES-SA cells by over 50% at 5 and 10 μM after 72 hours, without cytotoxic effects on HEK293 human embryonic kidney cells after 24 hours of exposure, indicating selective action[1]. |
| In vivo | The SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) effectively suppresses tumor growth in xenograft mice[1]. Utilizing Balb/c nude mice (18-20 g; 6-8 weeks old) implanted with MES-SA cells[1], the dosage administered was 2 mg/kg via intraperitoneal injection over a three-week period, excluding weekends. The outcome was a significant inhibition of cancer growth in vivo. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 250 mg/mL (874.95 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 5 mg/mL (17.5 mM), Sonication is recommended.
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| Keywords | tumor | Sirtuin | SIRT-7 inhibitor 97491 | SIRT7 inhibitor 97491 | SIRT7 | p53 K373/382 | Inhibitor | inhibit | deacetylase | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Nicotinamide riboside malate | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Apoptosis Compound Library | Histone Modification Compound Library | DNA Damage & Repair Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Glutamine Metabolism Compound Library | Antioxidant Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
