| Name | SKA-111 |
| Description | SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.SKA-111 binds to the interface between the CaM N-valve and the S4-S5 junction and ameliorates Bradykinin-induced dilation of coronary arteries in the isolated rat heart, which can be used for the study of cardiovascular diseases. study of cardiovascular diseases. |
| In vitro | SKA-111 (1 μM; 5 min) causes KCa3.1 membrane hyperpolarization in porcine endothelial cells. SKA-111 induces significantly enhanced Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in porcine large coronary arteries (PCA).[1] |
| In vivo | SKA-111 (1 μM; Cardiac perfusion; Langendorff in rat hearts; ) improves Bradykinin-induced coronary artery dilation in isolated rat hearts. SKA-111 potentiated significantly the fall in coronary perfusion pressure (CPP) induced by 1 nM BK in the presence of the vasoconstrictor in isolated rat hearts.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 65 mg/mL (303.33 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (9.33 mM), Sonication is recommended.
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| Keywords | SKA-111 | PotassiumChannel | Potassium Channel | KCa3.1 channel |
| Inhibitors Related | Minoxidil sulfate | Tannic acid | Hydrochlorothiazide | 1,8-Cineole | Tetraethylammonium bromide | Ursodeoxycholic acid | Chenodeoxycholic acid | Minoxidil | Chlorzoxazone | 2,2,2-Trichloroethanol | Taurocholic acid sodium salt hydrate | Indapamide |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Neuroprotective Compound Library | Bioactive Compounds Library Max | Potassium Channel Targeted Library | Ion Channel Targeted Library |