| Name | SKF 81297 hydrobromide |
| Description | SKF 81297 hydrobromide is a selective agonist of the dopamine D1-like receptor, with a high affinity for both D1 and D5 subtypes (Ki = 1.9 nM). SKF 81297 hydrochloride exhibits central activity in vivo and is widely used to study the neuromodulatory effects of the dopamine system, particularly in studies related to cognitive function and motor activity, such as Parkinson's disease. |
| In vivo | SKF 81297 hydrobromide (0.05-0.3 mg/kg, intramuscularly) can stimulate MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to impair motor behavior in monkeys. [1] |
| Storage | store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 1 mg/mL (2.7 mM), Sonication is recommended. DMF : 20 mg/mL (53.96 mM), Sonication is recommended. Saline : 2 mg/mL (5.4 mM), Suspension. DMSO : 20 mg/mL (53.96 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.5 mg/mL (6.74 mM), Sonication is recommended.
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| Keywords | SKF-81297 Hydrobromide |
| Inhibitors Related | Trifluoperazine dihydrochloride | Clozapine N-Oxide | Mirtazapine | Butyrophenone | Promazine hydrochloride | ONC206 | Octopamine hydrochloride | L-DOPA | Creatine | Oxolinic acid | Mianserin hydrochloride | Fluphenazine dihydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Lipid Metabolism Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |