| Name | SM1-71 |
| Description | SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2.SM1-71 can be used as a kinase probe with anticancer activity and inhibits the proliferation of various cancer cell lines. |
| In vitro | Potently inhibiting the proliferation of H23 and Calu-6 non-small cell lung cancer cell lines in a concentration-dependent manner, SM1-71 (0.001-100 μM; 72 h) demonstrates its efficacy. Additionally, SM1-71 induces potent cytotoxicity within 72 hours, with nanomolar values for GR50 and negative GRmax values observed in eight of 11 cancer cell lines[1][2]. |
| Storage | Store at low temperature | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (215.54 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (8.62 mM), Sonication is recommended.
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| Keywords | threoninkinase | threonin kinase | TGF-β/Smad | TGFβ | TGFbeta/Smad | TGF-beta | TGFbeta | TGF-b/Smad | TGFb | TAK1 | Smad | SM-1-71 | SM171 | SM1 71 | Serinekinase | Serine/threonin kinase | Serine kinase | MAP3K | LIMKinase | LIMK1 | LIM Kinase | bone morphogenetic protein (BMP) | AP2associatedkinase1 | AP2 associated kinase 1 | AAK1(AP2associatedkinase1) | AAK1 (AP2 associated kinase 1) | AAK1 |
| Inhibitors Related | Melamine | Amlexanox | Hydrochlorothiazide | Ferulic Acid | Dasatinib | Ibrutinib | Nintedanib esylate | Formononetin | Pirfenidone | Lenvatinib | Pazopanib | Sodium new houttuyfonate |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Inhibitor Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | TGF-beta/Smad Compound Library | Anti-Cancer Active Compound Library |