| Name | SN 2 |
| Description | SN 2 is a novel and potent TRPML3 ion channel activator(EC50 = 1.13 μM). SN 2 also shares a similar antiviral effect against DENV2 and ZIKV. |
| In vitro | When activated with 10 μM SN-2, at -80 mV, the conductance of the TRPML3 channel is approximately 10 pS. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone.SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at 80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.83 mM), Sonication is recommended. DMSO : 16.67 mg/mL (65.28 mM), Sonication is recommended.
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| Keywords | TRPVChannel | TRPV Channel | TRPML3 | TRPML1 | TRPChannel | TRP Channel | Transient receptor potential channels | SN-2 | SN2 | SN 2 | Inhibitor | inhibit |
| Inhibitors Related | Rosiglitazone | Caffeic Acid | Camphor | Probenecid | Penicillin G potassium | Sorbic acid | 1,4-Cineole | (E)-3-(p-Tolyl)acrylaldehyde | trans-Cinnamaldehyde | Naringenin | Erythromycin estolate | Antiviral Agent 51 |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Multi-Target Compound Library | Anti-Viral Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library | Anti-Infection Compound Library |