| Name | SNC 80 |
| Description | SNC 80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment. |
| In vitro | SNC80 selectively targets and activates the μ-δ heteromer within HEK293 cells, displaying an EC50 value of 52.8 nM. It demonstrates significantly higher activity in cells coexpressing μ- and δ-opioid receptors compared to those solely expressing δ-opioid receptors or those coexpressing δ- and κ-opioid receptors [4]. |
| In vivo | SNC80 (10 mg/kg; intraperitoneal injection; once) significantly attenuated allodynia induced by Sumatriptan overuse in C57BL6/J mice [1]. |
| Storage | 02 | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 33.3 mg/mL (74.06 mM), , when pH is adjusted to 3 with HCl. Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.22 mM), Sonication is recommended.
|
| Keywords | δ-opioid receptor | SNC-80 | SNC 80 | OpioidReceptor | Opioid Receptor | NIH-10815 | NIH10815 |
| Inhibitors Related | Docusate sodium | Bevenopran | Mirtazapine | Matrine | (-)-Menthol | Cuminaldehyde | Progesterone | Naltrexone hydrochloride | Cebranopadol | BTRX-335140 | Bisacodyl | Mianserin hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Antidepressant Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Neurotransmitter Receptor Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library |
United States
