| Name | Sodium 4-phenylbutyrate |
| Description | Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations. |
| In vitro | In G93A transgenic ALS mice, Phenylbutyrate improves clinical symptoms and increases survival. It induces the expression of NF-κB p50 in G93A mice, while reducing the expression of cytochrome c and caspases. Additionally, in transgenic mouse models of Huntington's disease (HD), Phenylbutyrate elevates brain protein acetylation levels and reduces histone methylation levels. |
| In vivo | In prostate cancer cells, Phenylbutyrate induces apoptosis by diminishing the expression levels of the cell apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker Caveolin-1, and the angiogenesis promoter Vascular Endothelial Growth Factor, thereby weakening their activity. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 33.33 mg/mL (179.02 mM), Sonication is recommended.
DMSO : 33.33 mg/mL (179.02 mM), Sonication is recommended.
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| Keywords | Tributyrate | Sodium 4-phenylbutyrate | Sodium 4phenylbutyrate | Sodium 4 phenylbutyrate | Inhibitor | inhibit | Histone deacetylases | HDAC | Benzenebutyric acid | Autophagy | Apoptosis | 4-Phenylbutyric acid | 4-PBA |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Urea | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Manganese chloride (tetrahydrate) | Formamide | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | DNA Damage & Repair Compound Library | Methylation Compound Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
