Factory Provide High Quality GS-7977 PSI 7977 CAS 1190307-88-0 Sofosbuvir
Introduction
Product Name : Sofosbuvir
Other name:Isopropyl(2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-4-fluoro-3-hydroxy-4-methyChemicalbookltetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate;PSI-7977;GS-7977;PSI7977;GS7977;SOFOSBUVIR
CAS No.:1190307-88-0
MF:C22H29FN3O9P
Purity :99%
MW:529.45
Melting Point :122-124°C
Density :1.41
Appearance: white to off white powder
Storage :Sealed in dry,Sealed in dry,Room Temperature
Sofosbuvir is the world's first oral drug used to treat hepatitis c, one of the most important new drugs approved in the United States in 2013, developed by the American firm gilad science. When it comes to genotype specific hepatitis c, it eliminates the need for traditional injectable drug interferon (IFN).
Sofosbuvir is used to treat chronic hepatitis c virus (HCV) infection. It is the first safe and effective drug to treat HCV infection without IFN. There are several different types of HCV infections. Depending on the type of infection, treatment options can include sofosbuvir and ribavirin, or sofosbuvir, ribavirin and polyethylene glycol interferon alpha.
This product is used for the treatment of genotype 2 and genotype 3 chronic hepatitis C (hepatitis C) adult patients. It can improve the liver function, promote the regeneration of injured liver cells, improve the function of tissue cell respiration and oxygen respiration rate, and reduce the accumulation of fat in the liver.
| Items | Specifications | Test results |
| Appearance | White to off-white crystalline powder | Conforms |
| Identification |
| High-performance liquid chromatograph HPLC | The retention time of the test sample major peak complies to reference standard | Conforms |
| Inspection |
| Water | ≤1.0% | 0.2% |
| Residue on Ignition | ≤0.1% | Conforms |
| Heavy metals | ≤20ppm | Conforms |
| Related Impurities | Total impurities ≤1.5% | 0.65% |
| Single impurity ≤0.5% | Conforms |
| Purity (HPLC) | ≥98.5% | 99.35% |
Application of Sofosbuvir
Sofosbuvir is used raw material of New drugs treating chronic hepatitis C.
1. Sofosbuvir is a kind of hepatitis c virus (HCV) NS5B polymerase inhibitors nucleotide analogues, applicable to as united antiviral treatment composition in the treatment of chronic hepatitis c (CHC) infection.
2. sofosbuvir confirmed by test can effectively treat genotype 1, 2, 3, or 4 c subjects, including within milan criteria are awaiting liver transplantation of HCC subjects and co-infection of HCV/HIV - 1 subjects.
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