| Name | Sophocarpine |
| Description | Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. |
| In vitro | Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. [1] Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. [2] In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. [3] |
| In vivo | Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. [1] LD50: Mice 63.94 mg/kg (i.v.) [4] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 49 mg/mL (198.9 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.12 mM), Sonication is recommended.
H2O : 5 mg/mL (20.3 mM), Sonication is recommended.
DMSO : 250 mg/mL (1014.82 mM), Sonication is recommended.
|
| Keywords | TLR | STAT | Sophocarpine | Protein kinase B | PotassiumChannel | Potassium Channel | PKB | PI3K | Phosphoinositide 3-kinase | p38MAPK | p38 MAPK | NF-κB | NFκB | NF-kB | NFkB | JNK | Inhibitor | inhibit | Influenza Virus | IFN-γ | hERG | ERK | Autophagy | Apoptosis | Akt |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Guanidine hydrochloride | Hydroxychloroquine | Ethyl linoleate | Formamide | Paeonol | Naringin | Trometamol | Gluconate Calcium | Alginic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Miao medicine Compound Library | Anti-Aging Compound Library | Anti-virus Traditional Chinese Medicine Monomer Library | Southwest China Geo-authentic Herb Compound Library | Ion Channel Targeted Library | Food as Medicine Compound Library |
United States
