| Name | Squalene |
| Description | Squalene (AddaVax) is an intermediate in cholesterol synthesis. Squalene has a variety of pharmacological properties, such as antilipemic, hepatoprotective, anti-atherosclerotic, cardioprotective, antioxidant, antitumor and antifungal. |
| In vitro | METHODS: Human MCF7, NCI-H460, and SF-268 cells were treated with Squalene (0-50 μM) for 72 hours, and MTS reduction assay was used to detect cell growth inhibition.
RESULTS: Squalene did not inhibit the proliferation of MCF7, NCI-H460 and SF-268 cells (IC50>50 μM). [1]
METHODS: MCF10A epithelial cells were treated with Squalene (12.5, 50, and 200 μM) for 24 hours, and ROS levels were measured using a microplate reader.
RESULTS: Squalene reduced intracellular ROS levels. [2] |
| In vivo | METHODS: To study the effect of Squalene on lipid parameters, mice were fed a diet containing Squalene (0.25-1 g/kg) for 11 weeks.
RESULTS: Squalene promoted the changes of HDL-cholesterol and paraoxonase 1, and decreased the reactive oxygen species in lipoproteins and plasma malondialdehyde levels. [3] |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (8.03 mM), Sonication is recommended.
Ethanol : 100 mg/mL (243.47 mM)
DMSO : 100 mg/mL (243.47 mM)
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| Keywords | Squalene | ReactiveOxygenSpecies | Reactive Oxygen Species | Fungal | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Calcium Propionate | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Benzyl propionate | Ethyl linoleate | Formamide | Glycerol | Thymidine | Gluconate Calcium |
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