| Name | SR-717 |
| Description | SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens. |
| In vitro | METHODS: Macrophage THP1 were treated with SR-717 (3.6 µM) for 10 min-6 h. The expression levels of target proteins were detected using Western Blot.
RESULTS: SR-717 activates p-STING, and its downstream p-TBK1, p-IRF3, p-p65, p-STAT1 and p-STAT3. [1]
METHODS: Primary human peripheral blood mononuclear cell PBMCs were treated with SR-717 (10 µM) for 2-6 h. Gene expression levels were detected using RT-qPCR.
RESULTS: SR-717 stimulated the activation of IFNB1, CXCL10 and IL6. [1] |
| In vivo | METHODS: To test the antitumor activity in vivo, SR-717 (30 mg/kg) was injected intraperitoneally into WT or Stinggt/gt C57BL/6 mice bearing mouse cutaneous melanoma tumor B16.F10 once daily for seven days.
RESULTS: SR-717 inhibited tumor growth as well as prolonged the survival time of mice with rhabdomyosarcoma. The antitumor effect of SR-717 showed an enforced dependence on STING expression, and a lack of activity was observed in Stinggt/gt mice. [1]
METHODS: To assay antitumor activity in vivo, SR-717 (10 mg/kg) was administered intravenously three times every two days to C57BL/6 mice harboring mouse cutaneous melanin tumor B16.F10.
RESULTS: SR-717 has anti-tumor activity in vivo and prolongs survival. [2] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 20 mg/mL (56.95 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.5 mg/mL (7.12 mM), Suspension.
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| Keywords | TMEM173 | THP1 | STING | Stimulator of Interferon Genes | SR-717 | SR717 | SR 717 | PD-L1 | MPYS | MITA | mimetic | ISG-THP1 | Inhibitor | inhibit | immunity | ERIS | cGAMP | antitumor |
| Inhibitors Related | 2',3'-cGAMP sodium | ChX710 | STING ligand-1 | STING agonist-4 | SN-008 | Omaveloxolone | diABZI STING agonist-1 | Cridanimod | C-176 | CCCP | diABZI STING agonist-1 trihydrochloride | C-178 |
| Related Compound Libraries | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | NO PAINS Compound Library | Immuno-Oncology Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
