| Name | (S,R,S)-AHPC-Me dihydrochloride |
| Description | (S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound used in the synthesis of ARV-771. ARV-771 is a BET PROTAC degrader that relies on von Hippel-Landau (VHL) E3 ligase and exhibits potent degradation of BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound acts as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, facilitating the recruitment of von Hippel-Lindau (VHL) protein. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (193.23 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 5 mg/mL (9.66 mM), Sonication is recommended.
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| Keywords | VHL ligand 2 Dihydrochloride | VHL ligand 2 | VHL | E3 ligase Ligand 1 Dihydrochloride | E3 ligase Ligand 1 | AHPC-Me Dihydrochloride | AHPC-Me | 1948273-02-6 free base | 1948273-02-6 | (S,R,S)AHPCMe dihydrochloride | (S,R,S) AHPC Me dihydrochloride |
| Inhibitors Related | Lenalidomide-Br | Pomalidomide 4'-alkylC3-acid | PT-179 | (S)-Thalidomide | Thalidomide | (S,R,S)-AHPC | Pomalidomide | Amino-PEG1-C2-acid | Lenalidomide | (S,R,S)-AHPC hydrochloride | 5-Aminothalidomide | Thalidomide 5-fluoride |