| Name | SSD114 HCl |
| Description | SSD114 is a novel GABAB receptor positive allosteric modulator. |
| In vitro | In conditions containing 10 μM GABA, 25 μM SSD114 hydrochloride significantly increased the level of [35S]GTPγS activation induced by GABA alone to approximately 170% of basal levels.SSD114 hydrochloride (15 or 30 μM) caused a shift in the GABA concentration-response curve to the left and at the highest concentration slightly increased the maximal stimulatory effect of GABA. In the co-presence of 15 and 30 μM SSD114 hydrochloride, the EC50 of GABA was reduced by 2-fold and 2.5-fold, respectively, while the maximal stimulatory effect (Emax) was enhanced only at the 30 μM concentration to 161 ± 5.09% of the basal value [1]. |
| In vivo | SSD114 hydrochloride pretreatment significantly shortened the onset time of the loss-of-orientation reflex (LORR) [F(5,30)=4.55, P<0.005]. Follow-up analyses showed that the onset time of LORR was significantly shorter in the group of mice that received pretreatment at doses equal to or higher than 10 mg/kg SSD114 hydrochloride compared to the control group. In addition, SSD114 hydrochloride pretreatment prolonged the duration of LORR [F(5,30)=4.81, P<0.005]. Follow-up analysis indicated that the LORR duration was significantly prolonged in the group of mice receiving 10 and 100 mg/kg SSD114 hydrochloride pretreatment compared to the control group [1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45 mg/mL (116.03 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.5 mg/mL (6.45 mM), Sonication is recommended.
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| Keywords | SSD-114 hydrochloride | SSD114 Hydrochloride | SSD 114 Hydrochloride | GABAReceptor | GABAB | GABA Receptor |
| Inhibitors Related | Valproic acid sodium salt | p-Hydroxybenzaldehyde | Urethane | Baicalin | Penicillin G sodium salt | Valproic Acid | Methyl eugenol | (-)-α-Pinene | Nipecotic acid | Methionine | Dihydromyricetin | Isoflurane |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Ion Channel Targeted Library | Anti-Cancer Compound Library |
United States
