| Name | SU0268 |
| Description | SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor that regulates inflammatory responses during Pseudomonas aeruginosa infection. |
| In vitro | SU0268/IACS-4759 (5-20 μM, 48h) co-treated cells are more viable than the correspondingly-treated IACS-4759- or SU0268-treated cells[1]. MTH1-depleted cells are less sensitive to the OGG1-specific inhibitor, SU0268 (5-10 μM), compared to their control shGFP counterparts[1]. SU0268 does not bind DNA and thus interacts with OGG1 specifically rather than its substrate[2]. SU0268 induces the release of type I IFN by the mitochondrial DNA-cGAS-STING-IRF3-IFN-β axis, which decreases bacterial loads and halts disease progression[3]. |
| In vivo | In MH-S cells and C57BL/6N mice, SU0268 pretreatment (10 mg/kg, intranasally treated) increases survival rates compared with controls without SU0268 pretreatment [3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (8.41 mM), Sonication is recommended.
DMSO : 100 mg/mL (210.28 mM), Sonication is recommended.
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| Keywords | SU-0268 | SU0268 | SU 0268 | STING | OGG1 | MCF-7 | IRF3 | Inhibitor | inhibit | HeLa | glycosylase | cGAS | antibacterial | A549 | 8-oxoguanine DNA glycosylase 1 (OGG1) |
| Inhibitors Related | Alendronate sodium trihydrate | Serotonin hydrochloride | Serotonin | Rosmarinic acid | D(+)-Raffinose pentahydrate | Risedronic Acid | 3-Methoxybenzamide | Entacapone | CBHcy | (-)-Gallocatechin gallate | Flopropione | Tolcapone |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
United States
