Sulbutiamine CAS:3286-46-2 With High Purity
Product Name:Sulbutiamine
Synonyms:arcalion;BISIBUTIAMINE;SULBUTIAMINE;Bisibuthiamine;SULBUTIAMINE(ARCALION,BISIBUTIAMINE);O,O-Diisobutyrate;3,3'-Dithiobis[4-[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-formylamino]-3-penten-1-ol] bis(2-methylpropionate);Bis(2-methylpropionic acid)[dithiobis[3-[1-[[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino]ethylidene]-3,1-propanediyl]] ester
CAS:3286-46-2
MF:C32H46N8O6S2
MW:702.89
EINECS: 221-937-3
Melting point:140.5-141.5 °C
Boiling point:892.5±65.0 °C(Predicted)
density:1.1323 (rough estimate)
refractive index:1.7400 (estimate)
storage temp.:under inert gas (nitrogen or Argon) at 2-8°C
solubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Chemical Properties:Sulbutiamine is a white solid. It is a synthetic compound, which consists of two thiamine molecules bound together by a sulfur group. Due to the fact that sulbutiamine is a dimer of two thiamine molecules, it is a lipophilic drug that crosses the blood-brain barrier more quickly than thiamine(Farid and Abdelwahab,2016).Thus, sulbutiamine has neurotropic action and can increases the levels of thiamine and thiamine phosphate esters in the brain (Sevim et al.,2017).
Uses:Sulbutiamine (isobutyryl thiamine disulfide) is a lipophilic derivative of thiamine used for the treatment of asthenia and other related pathological conditions. Sulbutiamine is available over-the-counter in several countries as a component of nutritional supplements.
Description
Sulbutiamine is a vitamin B1 derivative developed by the French Servier Pharmaceuticals. The product is described in Special Drug Patent 5921M as a formulation with vitamin B1 activity, which is able to increase the blood level of vitamin B1 and has a therapeutic effect on all vitamin B1 deficiencies.
China
