| Name | Sulfamerazine |
| Description | Sulfamerazine (RP2632) is a long-acting sulfanilamide antibacterial agent. Sulfamerazine inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for the binding site on dihydropteroate synthase. |
| In vitro | Sulfamerazine significantly affects the lifespan of rats, markedly prolonging the life of male hamsters. The maximum body weight of all rats fed with sulfamerazine exceeded that of the control group. After oral administration of sulfamerazine, significant alterations in the shape of the concentration-time curve due to age were observed, strongly indicating absorption deficiencies within the first week after birth in lambs. |
| In vivo | Sulfamerazine exhibits a bi-exponential decay in water and a tri-exponential decay in cyclodextrin (CD) solutions. The resonance of aromatic protons in Sulfamerazine indicates a significant upfield shift, suggesting that the aniline ring is deeply encapsulated within the CD cavity. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.57 mM), Sonication is recommended.
DMSO : 60 mg/mL (227.01 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | Sulfamerazine | RP-2632 | RP 2632 | Inhibitor | inhibit | DHPS | Bacterial | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | Hemin | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Bioactive Compound Library | Approved Drug Library | Antibiotics Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Bacterial Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
