| Name | Sulfathiazole |
| Description | Sulfathiazole (2-Sulfanilamidothiazole), an organosulfur compound, has been served as a short-acting sulfa medicine. |
| In vitro | Sulfathiazole (20 μg/L) begins degrading between days 31 and 38 in one of two batch reactors with different wastewater matrices, at a faster rate than sulfamethoxazole or sulfamethazine in the nitrification process (S3). [1] Recovery from spiked manure slurry samples is 64% for Sulfathiazole at pH 9. Sulfathiazole, with a pKa of 7.1 and retention times (tR) of 7.8, shows S/N values above 100 at the 1 mg/kg level. [2] Its sorption to inorganic sorbents is pH-dependent, influenced by sorbate speciation and sorbent charge properties, with cations being most significant for clay mineral sorption, followed by neutral species. [3] Sulfathiazole possesses at least five polymorphic forms: I, II, III, IV, and V and exists in the solid state in the imido form. [4] Sulfathiazole (94.9 mg/L) significantly increases reactive oxygen species (ROS) generation and lipid peroxidation under ultraviolet B (UV-B) light exposure, upregulates alpha-esterase, hemoglobin, and vitellogenin mRNA, and significantly affects daphnid survival. [5] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (176.25 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | sulfonamide | Sulfathiazole | Inhibitor | inhibit | DHPS | Bacterial | bacteria | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Stavudine | Ampicillin sodium | Kanamycin sulfate | Sodium 4-phenylbutyrate | Sulfamethoxazole sodium | Hydroxychloroquine | Guanidine hydrochloride | Doxycycline | Paeonol | Naringin | Dimethyl sulfoxide |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | ReFRAME Related Library | Antibiotics Library | Drug Repurposing Compound Library | Drug-Fragment Library | Anti-Bacterial Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
