| Name | Sulindac sulfide |
| Description | Sulindac sulfide (cis-Sulindac sulfide) is a non-steroidal anti-inflammatory compound that has a high affinity for COX-1 and acts as an inhibitor in Ras activation of Raf-1. Sulindac sulfide is a non-competitive inhibitor of gamma-secretase with an IC50 value of 20.2 μM. It is an active metabolite of sulinic acid. |
| In vitro | Treatment with 100 μM of Sulindac sulfide (SSide) induces apoptosis leading to significant reduction in Aβ generation and total protein expression. The IC50 for Aβ42 secretion of SSide is 30.6±2.8 μM. SSide inhibits γ42-secretase activity dose-dependently, with an IC50 of 20.2±2.6 μM. Increasing SSide concentration decreases the slope in the rate vs. enzyme concentration plot, indicating SSide is not an irreversible or pseudo-irreversible inhibitor. After pretreatment of the dialyzed solubilized γ-secretase fraction with SSide and subsequent exposure to CHAPSO buffer without SSide, γ-secretase activity almost fully recovers. This strongly suggests that SSide targets the γ-secretase complex as a reversible inhibitor. [1] |
| In vivo | Sulindac sulfide also inhibits aldose reductase, blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications.[2]
Sulindac sulfide inhibits colorectal cancer growth both in vitro and in vivo.[5] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 250 mg/mL (734.41 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.88 mM), Sonication is recommended.
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| Keywords | γ42-secretase | Raf-1 | mAChR |
| Inhibitors Related | Adiphenine hydrochloride | 2-(Methylamino)benzoic acid | Urethane | Hexamethonium Bromide | Sorafenib | Adenine | Valproic Acid | 10-Undecen-1-ol | Mitotane | N,N-Dicyclohexylcarbodiimide | Arecoline | Lansoprazole sulfide |
| Related Compound Libraries | Reprogramming Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
United States
