| Name | Swertisin |
| Description | Swertisin, a novel herbal biomolecule, shows a strong antihyperglycemic action. Swertisin is an adenosine A1 receptor antagonist, is known to have antidiabetic, anti-inflammatory and antioxidant effects. |
| In vitro | To identify new agents that stimulate islet differentiation, we screened various compounds isolated from Enicostemma littorale using NIH3T3 cells and morphological changes were observed. Characterization was performed by semiquantitative RT-PCR, Q-PCR, immunocytochemistry, immunoblotting, and insulin secretion assay for functional response in newly generated islet-like cell clusters (ILCC). Reversal of hyperglycemia was monitored after transplanting ILCC in STZ-induced diabetic mice. Among various compounds tested, Swertisin, an isolated flavonoid, was the most effective in differentiating NIH3T3 into endocrine cells. Swertisin efficiently changed the morphology of NIH3T3 cells from fibroblastic to round aggregate cell cluster in huge numbers. Dithizone (DTZ) stain primarily confirmed differentiation and gene expression studies signified rapid onset of differentiation signaling cascade in Swertisin-induced ILCC. Molecular imaging and immunoblotting further confirmed presence of islet specific proteins. Moreover, glucose induced insulin release (in vitro) and decreased fasting blood glucose (FBG) (in vivo) in transplanted diabetic BALB/c mice depicted functional maturity of ILCC. Insulin and glucagon expression in excised islet grafts illustrated survival and functional integrity. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50.00 mg/mL (112.01 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1.00 mg/mL (2.24 mM), Sonication is recommended.
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| Keywords | Swertisin | P1 receptor | Inhibitor | inhibit | AdenosineReceptor | Adenosine Receptor | A1 |
| Inhibitors Related | Theophylline monohydrate | Dapagliflozin | Lamivudine | Cetylpyridinium Chloride | Tenofovir Disoproxil Fumarate | Inosine | Theobromine | Thiamine hydrochloride | Theophylline | Nicotinamide | Tenofovir | Doxofylline |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Inhibitor Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Anti-virus Traditional Chinese Medicine Monomer Library | GPCR Compound Library | Food as Medicine Compound Library |
United States
