| Name | TABERSONINE HYDROCHLORIDE |
| Description | TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity. |
| In vivo | TABERSONINE HYDROCHLORIDE is an indole alkaloid mainly isolated from Catharanthus roseus, and a potential drug candidate for treatment of cancer and Alzheimer's disease (AD), however, its anti-inflammatory effect has not been revealed.TABERSONINE HYDROCHLORIDE ameliorated lipopolysaccharides (LPS)-induced ALI in vivo and inhibited LPS-mediated macrophage activation in vitro. By using murine ALI model, we found that TABERSONINE HYDROCHLORIDE significantly attenuated LPS-induced pathological injury in the lung. TABERSONINE HYDROCHLORIDE also inhibited LPS-mediated neutrophil infiltration, elevation of MPO activity and the production of TNF-α, IL-6 and IL-1β. Furthermore, TABERSONINE HYDROCHLORIDE inhibited LPS-induced the production of pro-inflammatory mediators such as iNOS, NO and cytokines by suppressing NF-κB and p38 MAPK/MK2 signaling cascades. TABERSONINE HYDROCHLORIDE HYDROCHLORIDE reduced the K63-linked polyubiquitination of TRAF6. Taken together,TABERSONINE HYDROCHLORIDE has anti-inflammatory activities in vitro and in vivo, and is a potential therapeutic candidate for the treatment of ALI/ARDS[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 3 mg/mL (8.05 mM), Sonication is recommended.
DMSO : 50 mg/mL (134.09 mM), Sonication is recommended.
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| Keywords | βAmyloid | β Amyloid | TABERSONINE HYDROCHLORIDE | Tabersonine | LI/ARDS | Inhibitor | inhibit | BetaAmyloid | Beta Amyloid | bAmyloid | b Amyloid | Aβ(1-42) | Aβ |
| Inhibitors Related | Kaolin | Stavudine | Aceglutamide | Urea | D(+)-Raffinose pentahydrate | Metronidazole | Hydroxypropyl Cellulose | Ethyl linoleate | Formamide | Naringin | Gluconate Calcium | Alginic acid |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Alkaloid Natural Product Library | Selected Plant-Sourced Compound Library | Inhibitor Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Covalent Natural Product Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Transcription Factor-Targeted Compound Library |
United States
