Tadalafil NEW

Factory Directly supplyTadalafil CAS: 171596-29-5 For Sex enhancement

IUPAC Name：(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Chemical Formula：C₂₂H₁₉N₃O₄

Molecular Weight:389.41 g/mol

Chemical Structure:A complex, rigid structure featuring a β-carboline and a methylenedioxyphenyl group, which contributes to its high lipophilicity and long half-life.

Appearance:White to off-white crystalline powder.

Solubility:Practically insoluble in water.

• Freely soluble in dimethylformamide (DMF) and dimethyl sulfoxide (DMSO).

• Slightly soluble in methanol and ethanol.

Melting Point:Approximately 298–302 °C (with decomposition).

pKa:~ 16.7 (acts as a weak base).

Log P (Octanol/Water):~ 2.5 (indicative of high lipophilicity).

Pharmacological Action:Inhibits PDE5, preventing the degradation of cyclic guanosine monophosphate (cGMP). Elevated cGMP leads to smooth muscle relaxation and increased blood flow in the corpus cavernosum (for ED) and the prostate/bladder (for BPH).

Primary Uses      

1. Treatment of Erectile Dysfunction (ED).

2. Treatment of signs and symptoms of Benign Prostatic Hyperplasia (BPH).

3. Treatment of Pulmonary Arterial Hypertension (PAH)

Key Features      

• Long half-life (~17.5 hours) allowing for flexible, on-demand, or once-daily dosing.

• Efficacy is not affected by food intake.

• Metabolized primarily by the hepatic enzyme CYP3A4.

• Structurally distinct from sildenafil and vardenafil, leading to different pharmacokinetics.

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