| Name | Talipexole dihydrochloride |
| Description | Talipexole dihydrochloride (Domnin) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, respectively. It displays antiParkinsonian activity. |
| In vivo | Intracisternal injection of 10 μg/kg Talipexole dihydrochloride promotes vagal-mediated reflex bradycardia induced by injection of angiotensin in β-adrenoceptor-blocked dogs. Intravenous administration of Talipexole dihydrochloride at 30 mcg/kg initially caused an increase in blood pressure in cats. Then there is the long-term drop in blood pressure and heart rate[4]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 1 mg/mL (3.54 mM), Sonication is recommended. DMSO : 10 mg/mL (35.43 mM), Sonication is recommended.
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| Keywords | α2-adrenergic receptor | Talipexole Dihydrochloride | Talipexole | Serotonin Receptor | Inhibitor | inhibit | DopamineReceptor | Dopamine Receptor | D2 | B-HT-920 Dihydrochloride | B-HT920 Dihydrochloride | B-HT-920 | B-HT920 | B-HT 920 Dihydrochloride | B-HT 920 | Beta Receptor | AdrenergicReceptor | Adrenergic receptor α-2, rat | Adrenergic Receptor | 5-hydroxytryptamine Receptor | 5HTReceptor | 5-HT3 | 5-HT Receptor | 5HT Receptor |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | Cefaclor monohydrate | Hexamethonium Bromide | Octopamine hydrochloride | 1,8-Cineole | L-DOPA | Isoprenaline hydrochloride | Creatine | D-Mannitol | Mianserin hydrochloride | Cinchonidine |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |