| Name | Tannic acid |
| Description | Tannic acid (Gallotannic acid) is a novel hERG channel blocker. |
| In vitro | METHODS: Rat cardiomyocytes H9C2 were treated with Tannic acid (5-50 µM) for 24 h. Cell viability was determined by CCK-8 Assay.
RESULTS: Treatment of H9C2 cells with Tannic acid concentration ≥ 30 µM resulted in a significant decrease in cell viability. [1]
METHODS: Human lung cancer cells A549 were treated with Tannic acid (20-60 µM) for 24-48 h. Cell cycle was measured by Flow cytometry.
RESULTS: Tannic acid inhibited cell viability in a dose-dependent manner at 24 h, with higher inhibition after 48 h. The IC50 values for Tannic acid were estimated to be in the range of 40-60 µM at 24 h and 20-40 µM at 48 h. [1] METHODS: Human lung cancer cells A549 were treated with Tannic acid (20-60 µM) for 24-48 h. Cell cycle was measured by Flow cytometry. [2] |
| In vivo | METHODS: To investigate the effects on oxidative stress mice, Tannic acid (2.5-10 mg/kg) was administered orally to diquat-induced oxidative stress C57BL/6J mouse model once daily for ten days.
RESULTS: Tannic acid pretreatment in the oxidative stress mouse model failed to alter antioxidant enzymes but modulated jejunal morphology, colon length, antioxidant pathways, and intestinal barrier in the diquat oxidative model. [3] |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 25 mg/mL (14.7 mM), Sonication is recommended.
H2O : 17.24 mg/mL (10.13 mM), Sonication is recommended.
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| Keywords | Tannic acid | PotassiumChannel | Potassium Channel | hERG | CXCR |
| Inhibitors Related | Minoxidil sulfate | Hydrochlorothiazide | (±)-Naringenin | Tetraethylammonium bromide | Halothane | Ursodeoxycholic acid | Neratinib | Cloperastine hydrochloride | Nifedipine | 2,2,2-Trichloroethanol | Indapamide | Nicotinamide N-oxide |
| Related Compound Libraries | Polyphenolic Natural Product Library | Traditional Chinese Medicine Monomer Library | Anti-COVID-19 Traditional Chinese Medicine Compound Library | Toxic Compound Library | Chinese Pharmacopoeia Natural Product Library | Cosmetic Ingredient Compound Library |
United States
