| Name | Taurodeoxycholic acid |
| Description | Taurodeoxycholic acid (Taurodeoxychloic acid) is a bile acid taurine conjugate of deoxycholic acid, a human metabolite that stabilizes mitochondrial membranes and reduces the formation of free radicals.Taurodeoxycholic acid inhibits apoptosis by blocking calcium-mediated apoptotic pathways and by activation of caspase-12. Taurodeoxycholic acid has neuroprotective activity and has been used to study 3-nitropropionic acid-induced or stabilized hereditary Huntington's chorea (HD). |
| In vitro | Taurodeoxycholic acid (50, 100 μM; 4 h) increases oligonuclear DNA cleavage and nuclear apoptosis in primary human hepatocytes.[1]
Taurodeoxycholic acid (400 μM; 18-24 h) increases DNA fragmentation and PARP cleavage and induces apoptosis in human liver-derived Huh7 cells.[2] |
| In vivo | Taurodeoxycholic acid (50 mg/kg; i.p.; once daily for 34 days; Huntington's disease model in mice) prevents neuropathology and associated behavioral deficits in a rat model of Huntington's disease (HD).[3]
Taurodeoxycholic acid (500 mg/kg; subcutaneous injection; every 3 days for 7 weeks; Huntington's disease model in mice) resulted in a significant reduction in striatal neuropathology in R6/2 transgenic HD mice.[4] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4 mM), Sonication is recommended. DMSO : 50 mg/mL (100.06 mM), Sonication is recommended.
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| Keywords | Taurodeoxycholic acid | Caspase | CalciumChannel | Calcium Channel | Ca(2+) receptor | Apoptosis |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | 2,4,6-Tri-tert-butylphenol | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Ethyl linoleate | Malic acid | Glycerol | Thymidine | Gluconate Calcium |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Natural Product Library | Microbial Natural Product Library | Neuroprotective Compound Library | Natural Product Library for HTS | Metabolism Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Ion Channel Targeted Library |