| Name | Taurolidine |
| Description | Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity. |
| Cell Research | In the in vitro experiments, DHD/K12/TRb cells were incubated with 5, 10, 15, 25, microg/ml of Taurolidine.?Cells incubated in culture medium alone were used as controls.?Cell proliferation, cell viability, cell death, and cell apoptosis were measured using commercially available techniques[1]. |
| Animal Research | In the in vivo experiment, BD IX rats were randomized into two groups (n = 10/group).?Group A (control) underwent laparotomy and instillation of DHD/K12/TRb tumor cells intraperitoneally followed by phosphate buffered saline (PBS).?Group B received Taurolidine (100 mg/kg) instead of PBS.?Animals were killed after 24 days and tumor burden assessed by counting the number of tumor nodules in the peritoneal cavity[1]. |
| In vitro | Incubation of the tumor cells with Taurolidine resulted in a 4-fold decrease in proliferation rates (25+/-4% vs. 100+/-28% for controls) and a 4-fold increase in cell necrosis as demonstrated by the increase in LDH release (403+/-28% vs. 100+/-26% for controls), at a Taurolidine concentration of 25 microg/ml.?A dose-dependent decrease in cell viability was also observed[1]. |
| In vivo | In vivo, local Taurolidine administration resulted in significant decreases in tumor burden (3+/-1 nodules in Group B animals vs. 649+/-101 nodules in Group A animals)[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.03 mM), Sonication is recommended.
DMSO : 50 mg/mL (175.83 mM), Sonication is recommended.
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| Keywords | venous | Taurolidine | Inhibitor | inhibit | infections | CVC | CRBSI | central | catheters | catheter-related | Bacterial | Apoptosis | antiseptic | antimicrobial | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | Hemin | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Sulfamethoxazole sodium | Terbinafine hydrochloride | Formamide | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Anti-Fungal Compound Library | Drug Repurposing Compound Library | NO PAINS Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Human Metabolite Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
