Factory Provide Natural Taxus Chinensis Extract Taxol Paclitaxel Powder CAS 33069-62-4
Introduction
Product Name : Paclitaxel
Other name: Taxol ; Taxus
CAS No.: 33069-62-4
MF: C47H51NO14
MW: 853.92
Melting Point :213 °C (dec.)(lit.)
Boiling Point :774.66°C (rough estimate)
Appearance: White to off white powder
Density :0.200g/cm3(Predicted)
Storage :Sealed in dry,Sealed in dry,Room Temperature
Taxol/ Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it 'taxol'. When it was developed commercially by Bristol-Myers Squibb (BMS) the generic name was changed to 'paclitaxel' and the BMS compound is sold under the trademark 'TAXOL'. In this formulation, paclitaxel is dissolved in Cremophor EL and ethanol, as a delivery agent. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane.
| TEST ITEM | SPECIFICATION | RESULTS |
| Appearance | White or almost white crystalline powder | White-crystalline Powder |
| Identification | Conform | Conform |
| Solubility | Soluble in ethanol, hardly soluble in water | Conform |
| Solubility in Polysorbate-80 | >=45.0mg/ml | Conform |
| Reconstitution Stability of 2ml of 45mg/ml solution of Docetaxel.trihydrate in polysorbate-80, with 6.0ml of 15.25% v/v absolute alcohol in water solution. The solution should be physically stable. No precipitation should be observed for at least 12 hours of storage of reconstituted solution at room temperature. |
| Specific Optical Rotation | -40°--47° | -41ºC |
| Microbial Limits |
| Total Aerobic Microbial Count | <=10000cfu/g | 60cfu/g |
| S. Aureus & Aeruginosa | Negative | Negative |
| Salmonella & E.Coli | Negative | Negative |
| Bacterial Endotoxins | <=0.4EU/mg | 0.15EU/mg |
| Moisture | <=3.0% | 0.5% |
| Residue of Ignition | <=0.2% | 0.05% |
| Heavy Metals | <=20ppm | 12ppm |
| Chromatographic Impurities |
| Highest individual Impurity | <=0.5% | 0.12% |
| Unknown Impurity | <=0.10% | Conform |
| Total Impurity | <=1.0% | Conform |
| Purity (HPLC) | >=99.5% | 99.52% |
| Conclusion | The lot meets the specifications |
Functions:
1. Paclitaxe is a mitotic inhibitor drup used in the treatment of cancer.
2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.
3. Paclitaxe has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.
Applications:
1.Taxol is a mitotic inhibitor drup used in the treatment of cancer.
2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.
3. Taxol has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.
4.Taxol is also used for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents.
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