| Name | TD139 |
| Description | TD139 is a small molecule inhibitor of inhaled galectin-3 (Gal-3) with potential anti-fibrotic activity, commonly used in the study of idiopathic pulmonary fibrosis. |
| In vitro | TD139 has a high affinity for galectin-3 with a Kd of 14 nM and 10 nM for galectin-1, but low affinity for galectins 2, 4N, 4C, 7, 8N, or 9N [1]. |
| In vivo | In primary lung AECs, TD139 reduces TGF-β1–induced β-catenin translocation to the nucleus, keeping most β-catenin at the cell surface, and blocks TGF-β1–induced β-catenin phosphorylation. TD139 treatment in WT mice results in a marked reduction in lung fibrosis and β-catenin activation, along with decreased galectin-3 expression [1]. Pretreatment of WT C57BL/6 mice with TD139 attenuates liver injury, reduces infiltration of IFNγ-, IL-17-, and IL-4-producing CD4(+) T cells, increases IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activated macrophages, and prevents apoptosis of liver-infiltrating MNCs [2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : Insoluble
Ethanol : 3 mg/mL (4.63 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.08 mM), Sonication is recommended.
DMSO : 55 mg/mL (84.79 mM), Sonication is recommended.
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| Keywords | TD-139 | TD139 | TD 139 | galectin-3 |
| Inhibitors Related | G3-C12 acetate(848301-94-0 free base) | N-Acetyl-D-galactosamine | Galectin-3 antagonist 2 | Thiodigalactoside | 4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid | N-acetyl-D-Lactosamine | SNAP 398299 | GB1107 | Selvigaltin | OTX008 | Galectin-3-IN-2 | G3-C12 |
| Related Compound Libraries | Nonsteroidal Anti-Inflammatory Compound Library | Bioactive Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Fibrosis Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Metabolism Disease Compound Library |
United States
