Tegoprazan NEW

$2.00 100kg

$4.00 10kg

$6.00 1kg

Min. Order1kg
Purity99%
Cas No942195-55-3
Supply Ability100kg
Update time2025-10-13

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

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China

Chemical Properties

Product Name	Tegoprazan
CAS No	942195-55-3
EC-No
Min. Order	1kg
Purity	99%
Supply Ability	100kg
Release date	2025/10/13

PRODUCT INFORMATION

Common Name	Tegoprazan
CAS Number	942195-55-3	Molecular Weight	387.38
Density	N/A	Boiling Point	N/A
Molecular Formula	C20H19F2N3O3	Melting Point	N/A
MSDS	N/A	Flash Point	N/A

Purity		Quantity		Budget		Inquiry

Use of Tegoprazan

Tegoprazan, a potassium-competitive acid blocker, is a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro[1].

Properties
Spectrum

Name	Tegoprazan

Description	Tegoprazan, a potassium-competitive acid blocker, is a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Research Areas >> Metabolic Disease
Target	IC50: 0.29-0.52 μM (H+/K+-ATPase)[1].
In Vitro	Tegoprazan inhibits porcine, canine, and human H+/K+-ATPase activity. Tegoprazan inhibits gastric H+/K+-ATPase in a potassium-competitive and reversible manner. Tegoprazan (3 μM) inhibits 86% of H+/K+-ATPase activity, whereas the inhibition is decreased to 34% after the dilution of Tegoprazan concentration to 0.15 μM[1].
In Vivo	Tegoprazan (1.0 mg/kg, p.o.) potently and completely inhibits histamine-induced gastric acid secretion in dogs. Tegoprazan (1.0-3.0 mg/kg, p.o.) reverses the pentagastrin-induced acidified gastric pH to the neutral range. Tegoprazan (3 mg/kg, p.o.) immediately evokes a gastric phase III contraction of the migrating motor complex in pentagastrin-treated dogs[1].
References	[1]. Takahashi N, et al. Tegoprazan, a Novel Potassium-Competitive Acid Blocker to Control Gastric Acid Secretion and Motility. J Pharmacol Exp Ther. 2018 Feb;364(2):275-286.

Molecular Formula	C20H19F2N3O3
Molecular Weight	387.38
Storage condition	-20°C

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