| Name | Telbivudine |
| Description | Telbivudine (NV 02B) is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of telbivudine is as a Nucleoside Reverse Transcriptase Inhibitor. The chemical classification of telbivudine is Nucleoside Analog. |
| In vivo | Telbivudine significantly increases the levels of tumor necrosis factor-alpha and interleukin-2 in macrophages (induced by MHV-3) as well as serum levels of interferon-gamma. It is phosphorylated by cellular thymidine kinase into an active triphosphate form, with an intracellular half-life of 14 hours. While enhancing the proliferation and secretion capabilities of T-cells, Telbivudine does not affect the cytotoxicity against infected hepatocytes. Furthermore, it inhibits the expression of programmed death ligand 1 in T-cells. Despite mutations such as N236T and A181V/A194T, Telbivudine remains active at increased magnitudes of 0.5 and 1.0 times, respectively. The differences in resistance between lamivudine and Telbivudine are due to Telbivudine's inactivity against the lamivudine-resistant HBV strain L180M/M204V/I mutation, though it remains active against the M204V single mutation. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 44 mg/mL (181.65 mM), Sonication is recommended.
DMSO : 50 mg/mL (206.42 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.5 mg/mL (10.32 mM), Sonication is recommended.
Ethanol : 2 mg/mL (8.26 mM), Heating is recommended.
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| Keywords | Telbivudine | ReverseTranscriptase | Reverse Transcriptase | Protein P | Inhibitor | inhibit | Hepatitis B virus | HBV |
| Inhibitors Related | Stavudine | Doxorubicin hydrochloride | Emtricitabine | Lamivudine | Cetylpyridinium Chloride | Tenofovir Disoproxil Fumarate | Pyridoxal phosphate | Tenofovir alafenamide | Thiamine hydrochloride | (Tetrahydro-2H-pyran-4-yl)methanol | Nicotinamide | Tenofovir |
| Related Compound Libraries | Bioactive Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Drug Library |
United States
